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Tetrazoles

Tetrazoles are doubly unsaturated five-membered aromatic heterocycles consisting of one carbon atom and four nitrogen atoms. Tetrazole derivatives are a major class of heterocyclic compounds that are important for medicinal chemistry and drug design because of their not only isosteric properties with carboxylic acid and amide moieties, but also metabolic stability and other beneficial physicochemical properties.

N-{2-methyl-1-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]propan-2-yl}benzenesulfonamide

N-benzyl-N-(propan-2-yl)-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3,4-tetrazole-5-carboxamide

N-benzyl-2-(4-fluorophenyl)-N-(propan-2-yl)-2H-1,2,3,4-tetrazole-5-carboxamide

N-{4-[4-(carbamoylmethyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

N-{4-[4-({[(furan-2-yl)methyl]carbamoyl}methyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide

N-{4-[4-({[(furan-2-yl)methyl]carbamoyl}methyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-5-methyl-1,2-oxazole-3-carboxamide

N-benzyl-4-{[1-(4-methylphenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}piperazine-1-carboxamide

N-{5-[(4-methylphenyl)methyl]-1,3-thiazol-2-yl}-4-(1H-1,2,3,4-tetrazol-1-yl)benzamide

N-{5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl}-3-(1H-1,2,3,4-tetrazol-1-yl)benzamide

N-{4-[4-({[(furan-2-yl)methyl]carbamoyl}methyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-3-methyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide

N-butyl-N,2-diphenyl-2H-1,2,3,4-tetrazole-5-carboxamide

N-{4-[4-(carbamoylmethyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-2-ethoxynaphthalene-1-carboxamide

N-{4-[5-(ethylsulfanyl)-1H-1,2,3,4-tetrazol-1-yl]phenyl}-1,2,3-benzothiadiazole-6-carboxamide

N-{4-[5-(ethylsulfanyl)-1H-1,2,3,4-tetrazol-1-yl]phenyl}-1-benzofuran-2-carboxamide

N-benzyl-4-[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-1,3-thiazol-2-amine hydrochloride

N-{4-[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-1,3-thiazol-2-yl}pyridin-3-amine hydrochloride

N-{5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl}-2-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]acetamide

N-{5-[(2,5-dichlorophenyl)methyl]-1,3-thiazol-2-yl}-4-(1H-1,2,3,4-tetrazol-1-yl)benzamide

N-{5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-yl}-4-(1H-1,2,3,4-tetrazol-1-yl)benzamide

N-{4-[5-(dimethylcarbamoyl)-2H-1,2,3,4-tetrazol-2-yl]phenyl}quinoxaline-2-carboxamide

N-{4-[5-(dimethylcarbamoyl)-2H-1,2,3,4-tetrazol-2-yl]phenyl}-1,3-benzothiazole-2-carboxamide

N-{4-[4-(carbamoylmethyl)-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl]phenyl}-4-(dimethylsulfamoyl)benzamide

N-benzyl-N-methyl-2-phenyl-2H-1,2,3,4-tetrazole-5-carboxamide

N-{2-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]phenyl}-2-[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]acetamide