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PRODUCT CATALOGUE

Imidazopyridazines

Potent IRAK-4 inhibitors have been reported by several groups including some structurally related benzimidazoles as well as alternative fused heterocycles such as the imidazopyridine and imidazopyridazine. Such compounds are reported to have IRAK-1 and IRAK-4 activity with varying degrees of selectivity.

7-Chloro-1H-imidazo[4,5-d]pyridazin-4(5H)-one
7-Chloro-1H-imidazo[4,5-d]pyridazin-4(5H)-one
CM516146
28683-00-3
2-Chloro-6-propylimidazo[1,2-b]pyridazine
2-Chloro-6-propylimidazo[1,2-b]pyridazine
CM522253
570416-05-6
2-Chloro-6-isopropylimidazo[1,2-b]pyridazine
2-Chloro-6-isopropylimidazo[1,2-b]pyridazine
CM522254
570416-42-1
2-Methylimidazo[1,2-b]pyridazin-6(5H)-one
2-Methylimidazo[1,2-b]pyridazin-6(5H)-one
CM523339
64179-55-1
Ethyl 6-chloro-2-phenylimidazo[1,2-b]pyridazine-3-carboxylate
Ethyl 6-chloro-2-phenylimidazo[1,2-b]pyridazine-3-carboxylate
CM527019
874779-81-4
6-Chloro-2-cyclopropylimidazo[1,2-b]pyridazine
6-Chloro-2-cyclopropylimidazo[1,2-b]pyridazine
CM529433
916257-51-7
6-(Pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
6-(Pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
CM530761
952182-09-1
3-Bromo-6-(pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
3-Bromo-6-(pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
CM530762
952182-15-9
6-Chloro-8-iodo-2-methylimidazo[1,2-b]pyridazine
6-Chloro-8-iodo-2-methylimidazo[1,2-b]pyridazine
CM563019
1298031-96-5
1-{3-Bromoimidazo[1,2-b]pyridazin-6-yl}piperidine
1-{3-Bromoimidazo[1,2-b]pyridazin-6-yl}piperidine
CM541593
952182-14-8
1-{Imidazo[1,2-b]pyridazin-6-yl}piperidine
1-{Imidazo[1,2-b]pyridazin-6-yl}piperidine
CM541594
952182-10-4
1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
CM545836
2452464-73-0
PF-06372865
PF-06372865
CM546234
1614245-70-3
(6-Methylimidazo[1,2-b]pyridazin-2-yl)methanamine
(6-Methylimidazo[1,2-b]pyridazin-2-yl)methanamine
CM548530
1201597-28-5
Ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate
Ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate
CM549284
1005786-10-6
Imidazo[1,2-b]pyridazine-2-carbaldehyde
Imidazo[1,2-b]pyridazine-2-carbaldehyde
CM552934
1369366-97-1
6-Iodoimidazo[1,2-b]pyridazine-2-carboxylic acid
6-Iodoimidazo[1,2-b]pyridazine-2-carboxylic acid
CM553157
1216380-53-8
2-Chloro-7-methylimidazo[1,5-b]pyridazine
2-Chloro-7-methylimidazo[1,5-b]pyridazine
CM567052
1352881-33-4
7-Chloro-4-iodoimidazolo[3,4-b]pyridine
7-Chloro-4-iodoimidazolo[3,4-b]pyridine
CM568945
1241800-23-6
(1R,8S)-8-Amino-4-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-7-ox o-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylate
(1R,8S)-8-Amino-4-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-7-ox o-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylate
CM574881
167271-60-5
2,6-Dimethylimidazo[1,2-b]pyridazine
2,6-Dimethylimidazo[1,2-b]pyridazine
CM574882
17412-39-4
methyl 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methylbenzoate
methyl 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methylbenzoate
CM577997
1356385-96-0
4H-Pyrido[1,2-a]pyrimidin-4-one,2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-
4H-Pyrido[1,2-a]pyrimidin-4-one,2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-
CM578259
1825352-87-1
2-[3-(hydroxymethyl)-4-[8-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]imidazo[1,2-b]pyridazin-6-yl]pyridin-2-yl]-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1-one
2-[3-(hydroxymethyl)-4-[8-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]imidazo[1,2-b]pyridazin-6-yl]pyridin-2-yl]-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1-one
CM589993
1433820-83-7