Nom du produit:tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate
IUPAC Name:tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate
- CAS:916420-27-4
- Formule moléculaire:C12H15Cl2N3O2
- Pureté:95%+
- Numéro de catalogue:CM104183
- Poids moléculaire:304.17
Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:916420-27-4
- Formule moléculaire:C12H15Cl2N3O2
- Point de fusion:-
- Code SMILES:CC(C)(C)OC(=O)N1CCC2=C(Cl)N=C(Cl)N=C2C1
- Densité:
- Numéro de catalogue:CM104183
- Poids moléculaire:304.17
- Point d'ébullition:
- N° Mdl:MFCD09025732
- Stockage:
Column Infos
- Adagrasib
- Jan. 10, 2024, EC approves KRAZATI (adagrasib) as a targeted treatment option for patients with advanced non-small cell lung cancer (NSCLC) with a KRAS G12C mutation.
Adagrasib is an orally available, potent, irreversible, small molecule inhibitor of KRAS G12C mutant isoform for the treatment of solid tumours harbouring KRAS G12C oncogenic driver mutation. Adagrasib covalently binds to the mutant cysteine in KRAS G12C and locks the mutant KRAS protein in its inactive state, thereby preventing downstream signalling without affecting wild-type KRAS protein.