Nom du produit:2-Ethylbutyric Acid
IUPAC Name:2-ethylbutanoic acid
- CAS:88-09-5
- Formule moléculaire:C6H12O2
- Pureté:95%+
- Numéro de catalogue:CM394240
- Poids moléculaire:116.16
Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:88-09-5
- Formule moléculaire:C6H12O2
- Point de fusion:-
- Code SMILES:CCC(CC)C(O)=O
- Densité:
- Numéro de catalogue:CM394240
- Poids moléculaire:116.16
- Point d'ébullition:
- N° Mdl:
- Stockage:
Column Infos
- KB-0742
- Kronos Bio announces the first patient dosed in an expansion cohort with KB-0742 at a dose of 80mg given on a four-days-on, three-days-off schedule. This expansion cohort is enrolling platinum-resistant patients with high-grade serous ovarian cancer (HGSOC). Many cancers exhibit transcriptional deregulation, often characterized by gene amplifications of MYC family oncogene. Targeting the transcription elongation cofactor, cyclin-dependent kinase 9 (CDK9) has emerged as a therapeutic strategy to disrupt MYC oncogenic activity.
KB-0742 is an oral highly selective CDK9 inhibitor designed for the treatment of patients with MYC-amplified and other transcriptionally addicted relapsed or refractory solid tumors, including ovarian, lung, and triple-negative breast cancers.