Recherche Recherche de structure
wx_img
Inquiry Form
  1. Accueil
  2. Category: Pyrimidines
  3. product Cas No.: 851443-04-4

Nom du produit:ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

IUPAC Name:ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

CAS：851443-04-4
Formule moléculaire：C24H32FN3O6S
Pureté：95%
Numéro de catalogue：CM128418
Poids moléculaire：509.59
Unité d'emballage Stock disponible Prix($) Quantité
CM128418-1g in stock ȌƼDzƋ
Demande: sales@chemenu.com
Pour une utilisation en R&D uniquement..

Formulaire de demande

   refresh    

Détails du produit

N° CAS:851443-04-4
Formule moléculaire:C24H32FN3O6S
Point de fusion:-
Code SMILES:O=C(OCC)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
Densité:
Numéro de catalogue:CM128418
Poids moléculaire:509.59
Point d'ébullition:699.1°C at 760 mmHg
N° Mdl:MFCD12756003
Stockage:Store at 2-8°C.

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

Related Products

1150560-54-5

1150560-54-5

1159977-25-9

1159977-25-9

1246610-76-3

1246610-76-3

1392804-15-7

1392804-15-7

147098-18-8

147098-18-8

Product Other Information

Product Overview Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a medication prescribed by physicians to treat high cholesterol levels. It is a member of the statin class of drugs, which are used to reduce cholesterol levels by blocking the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the body. It is also used to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is the generic name for the drug Crestor, which is manufactured by AstraZeneca.
Physical Properties Appearance: Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is a off-white to pale beige solid.
Solubility: The compound is slightly soluble in DMSO and methanol.
Chemical Properties Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate is an intermediate in the production of super statin Resuvastatin calcium.
Synthesis and Application Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has been studied extensively in clinical trials, and has been found to reduce LDL cholesterol levels, as well as total cholesterol levels. Additionally, it has been shown to reduce the risk of stroke, heart attack, and other cardiovascular diseases. Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate has also been studied in the laboratory setting, and has been found to have a number of beneficial effects on various biochemical and physiological processes.