cas 849217-48-7|| where to buy 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

Nom du produit:1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid

IUPAC Name:1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid

Unité d'emballage	Stock disponible	Prix($)
CM203349-50g	in stock	ȷȦȌ
CM203349-100g	in stock	ȷƼſ

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: N° CAS:849217-48-7; Formule moléculaire:C11H10FNO3; Point de fusion:-; Code SMILES:O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)O; Densité:

: Numéro de catalogue:CM203349; Poids moléculaire:223.2; Point d'ébullition:; N° Mdl:; Stockage:Store at room temperature.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

: Benzenes; Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.

: Cabozantinib; On August 21, 2023, Exelixis and Ipsen announced that the global phase 3 CONTACT-02 study of cabozantinib (Cabometyx ®) in combination with atezolizumab for metastatic castration-resistant prostate cancer (mCRPC) met the primary endpoint of progression-free survival (PFS) in an interim analysis.
Prostate cancer is the fourth most common cancer worldwide and the second most common cancer among men. At present, the drugs approved for the treatment of CRPC are basically AR inhibitors or PARP inhibitors, and the combination therapy of Cabozantinib + Atezolizumab is expected to become a new treatment option for such patients.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.