Nom du produit:2,3-Dihydro-1,4-benzodioxine-6-carbonyl chloride

IUPAC Name:2,3-dihydro-1,4-benzodioxine-6-carbonyl chloride

CAS:6761-70-2
Formule moléculaire:C9H7ClO3
Pureté:95%
Numéro de catalogue:CM156902
Poids moléculaire:198.6

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Détails du produit

N° CAS:6761-70-2
Formule moléculaire:C9H7ClO3
Point de fusion:-
Code SMILES:O=C(Cl)C1=CC=C2OCCOC2=C1
Densité:
Numéro de catalogue:CM156902
Poids moléculaire:198.6
Point d'ébullition:301.7°C at 760 mmHg
N° Mdl:MFCD02681889
Stockage:Store at 2-8°C.

Category Infos

Benzodioxanes
Benzodioxanes are a class of isomeric compounds with the molecular formula C8H8O2. The three isomers of benzodioxane are 1,2-benzodioxane, 1,3-benzodioxane and 1,4-benzodioxane. 1,4-Benzodioxane has long been a versatile template widely used to design molecules with diverse biological activities. Its use spans past decades in medicinal chemistry to today, involving many drug discovery strategies, not excluding the most advanced ones. 1,4-Benzodioxane derivatives have been described as agonists and antagonists of nicotinic, alpha-adrenergic and 5-HT receptor subtypes. 1,4-Benzodioxane derivatives have been also reported as antitumor and antibacterial agents.

Column Infos

NXP800
Nuvectis Pharma announces encouraging preliminary data from the NXP800 phase 1b clinical trial in platinum-resistant ARID1a-mutated ovarian cancer. There is a 33% response rate and 100% disease control rate in patients evaluated for efficacy.
Heat shock transcription factor 1 (HSF1) is critical for tumorigenesis and progression, and is implicated in multiple solid tumors. NXP800 is a potent, clinical stage inhibitor of the HSF1 pathway. The compound activates GCN2 kinase, that phosphorylates the eIF2α and later encodes the ATF4 transcription regulator, resulting in cancer cell death. NXP800 previously gets Fast Track Designation for platinum-resistant, ARID1a-mutated ovarian cancer.