Nom du produit:Bromonitromethane

IUPAC Name:bromo(nitro)methane

CAS:563-70-2
Formule moléculaire:CH2BrNO2
Pureté:95%+
Numéro de catalogue:CM422771
Poids moléculaire:139.94

Unité d'emballage Stock disponible Prix($) Quantité
CM422771-50g in stock ŗƥƥƥ
CM422771-100g in stock ŗĽĽĽ

Pour une utilisation en R&D uniquement..

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Détails du produit

N° CAS:563-70-2
Formule moléculaire:CH2BrNO2
Point de fusion:-
Code SMILES:[O-][N+](=O)CBr
Densité:
Numéro de catalogue:CM422771
Poids moléculaire:139.94
Point d'ébullition:
N° Mdl:MFCD00007401
Stockage:

Column Infos

Nanatinostat
Epstein–Barr virus (EBV) has been associated with malignant lymphomas of B-cell, T-cell, and NK-cell origin. EBV infection of lymphoma cells leads to the development of cancers with an unmet medical need. The innovative ‘Kick and Kill’ approach targets EBV with Nanatinostat and Valganciclovir, in which Nanatinostat activates Ganciclovir by inducing the expression of EBV kinase genes. Ganciclovir then converts to cytotoxic form and results in apoptosis
Histone deacetylase (HDAC) is involved in the regulation of gene expression. HDAC inhibition induces cell cycle arrest and reactivates normal expression of tumor cells. Nanatinostat is such a potent hydroxamic acid-based class I-selective HDAC inhibitor. Nanatinostat is being studied with the antiviral agent Valganciclovir in EBV-associated malignancies. Viracta Therapeutics recently reports positive topline Nana-val results from stage 1 of the NAVAL-1 Trial from both arms of the relapsed or refractory (R/R) Epstein-Barr virus-positive (EBV+) peripheral T-cell lymphoma (PTCL) cohort.