Nom du produit:2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethan-1-amine

IUPAC Name:2-{2-oxa-6-azaspiro[3.3]heptan-6-yl}ethan-1-amine

CAS:54384-40-6
Formule moléculaire:C7H14N2O
Pureté:95%
Numéro de catalogue:CM139052
Poids moléculaire:142.2

Unité d'emballage Stock disponible Prix($) Quantité
CM139052-10g in stock ǯƻŭȀ

Pour une utilisation en R&D uniquement..

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Détails du produit

N° CAS:54384-40-6
Formule moléculaire:C7H14N2O
Point de fusion:-
Code SMILES:NCCN(C1)CC21COC2
Densité:
Numéro de catalogue:CM139052
Poids moléculaire:142.2
Point d'ébullition:236.9°C at 760 mmHg
N° Mdl:MFCD13184501
Stockage:Keep in dark place, store at 2-8°C.

Category Infos

Spiro Compounds
A spiro compound is a polycyclic compound in which two monocyclic rings share one carbon atom; the shared carbon atom is called a spiro atom. Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. Compared with the monocyclic structure or the planar aromatic structure, the spiro structure has a larger three-dimensional structure; the heterocyclic spiro structure is also regarded as the biological isostere of some groups, which can change the drug to a certain extent. The water solubility, lipophilicity, dominant conformation and ADMET properties of the molecule make the optimized lead molecule easier to drug. Therefore, spiro compounds occupy a very important position in drug development.
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Azetidines
Azetidines are an important class of saturated four-membered nitrogen-containing heterocyclic compounds. The research hotspots related to this structure mainly focus on two aspects: one is the research of pharmaceutical chemistry; the other is related to chiral azetidines, using rigid azetidine compounds as chiral ligands for asymmetric catalytic reactions. Many nitrogen-containing heterocycles play important roles in drug structures, and in many cases small structural changes can improve ligand selectivity and pharmacokinetic properties.
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Oxetanes
Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.

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