Nom du produit:4-Amino-6-chloro-5-hydroxypyrimidine
IUPAC Name:4-amino-6-chloropyrimidin-5-ol
- CAS:38953-42-3
- Formule moléculaire:C4H4ClN3O
- Pureté:95%+
- Numéro de catalogue:CM116619
- Poids moléculaire:145.55
Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:38953-42-3
- Formule moléculaire:C4H4ClN3O
- Point de fusion:-
- Code SMILES:OC1=C(Cl)N=CN=C1N
- Densité:
- Numéro de catalogue:CM116619
- Poids moléculaire:145.55
- Point d'ébullition:312.5°C at 760 mmHg
- N° Mdl:MFCD13689013
- Stockage:Store at room temperature
Category Infos
- Pyrimidines
- Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
Column Infos
- Remibrutinib
- Novartis announced new positive data from the Phase III REMIX-1 and REMIX-2 studies investigating remibrutinib - a highly selective, oral Bruton's tyrosine kinase (BTK) inhibitor - in people with chronic spontaneous urticaria (CSU) whose symptoms are inadequately controlled by H1-antihistamines. In the studies, remibrutinib met all primary and secondary endpoints at Week 12. Remibrutinib is a potential 'best-in-class' BTK inhibitor. It can covalently bind to the BTK enzyme of B cells and myeloid cells. While strongly inhibiting BTK activity, it reduces the systemic exposure of the drug and reduces the risk of adverse events and drug interactions.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.