Nom du produit:(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

IUPAC Name:[(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-(2,6-dichloro-9H-purin-9-yl)oxolan-2-yl]methyl acetate

CAS:3056-18-6
Formule moléculaire:C16H16Cl2N4O7
Pureté:97%
Numéro de catalogue:CM138799
Poids moléculaire:447.23

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Détails du produit

N° CAS:3056-18-6
Formule moléculaire:C16H16Cl2N4O7
Point de fusion:-
Code SMILES:O=C(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2C=NC3=C(Cl)N=C(Cl)N=C23)O1)C
Densité:
Numéro de catalogue:CM138799
Poids moléculaire:447.23
Point d'ébullition:555.3°C at 760 mmHg
N° Mdl:MFCD02093101
Stockage:Keep in inert atmosphere, store at 2-8°C.

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Nucleosides and Nucleotides
Nucleosides consist of a nucleotide and a five-carbon sugar, and a nucleotide consists of a nucleotide, a five-carbon sugar, and one or more phosphate groups.
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Nucleosides
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose).
Namodenoson
Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson was evaluated in Phase II trials for two indications, as a second line treatment for hepatocellular carcinoma, and as a treatment for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Namodenoson granted Orphan Drug and Fast track status from the FDA. A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential effect accounts for the excellent safety profile of the drug.