cas 2869955-58-6|| where to buy 5-hydroxy-6-methyl-pyrimidine-4-carboxylic acid

Nom du produit:5-hydroxy-6-methyl-pyrimidine-4-carboxylic acid

IUPAC Name:5-hydroxy-6-methylpyrimidine-4-carboxylic acid

Unité d'emballage	Stock disponible	Prix($)
CM1051318-100mg	in stock	ŉȎȎ
CM1051318-250mg	in stock	ưůĽ

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: N° CAS:2869955-58-6; Formule moléculaire:C6H6N2O3; Point de fusion:-; Code SMILES:CC1=NC=NC(C(O)=O)=C1O; Densité:

: Numéro de catalogue:CM1051318; Poids moléculaire:154.13; Point d'ébullition:; N° Mdl:; Stockage:

: Pyrimidines; Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

: HRO761; Novartis'HRO761 is an oral allosteric inhibitor targeting WRN helicase, aimed at treating microsatellite instability (MSI) or deficient mismatch repair (dMMR) tumors. WRN has emerged as a critical synthetic lethal target in MSI cancers, which are common in colorectal, gastric, endometrial, and ovarian cancers. Although MSI cancers show a high response rate to immune checkpoint inhibitors, many patients develop resistance. By acting on WRN, HRO761 may be able to stop the growth of the cancer.
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