cas 2763157-90-8|| where to buy 5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

Nom du produit:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

IUPAC Name:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

: CAS：2763157-90-8; Formule moléculaire：C8H4Cl2FN3OS; Pureté：95%+

: Numéro de catalogue：CM1043992; Poids moléculaire：280.1

Unité d'emballage	Stock disponible	Prix($)
CM1043992-100mg	in stock	ƻƙǕ
CM1043992-250mg	in stock	ƻƋſ
CM1043992-1g	in stock	ǕȦƱ
CM1043992-5g	in stock	ƻƙƱƱ

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Détails du produit

: N° CAS:2763157-90-8; Formule moléculaire:C8H4Cl2FN3OS; Point de fusion:-; Code SMILES:CSC1=NC2=C(C(=O)N1)C(=NC(=C2F)Cl)Cl; Densité:

: Numéro de catalogue:CM1043992; Poids moléculaire:280.1; Point d'ébullition:; N° Mdl:; Stockage:

Category Infos

: Pyridopyrimidines

Column Infos

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.

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