Nom du produit:Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
IUPAC Name:{4-[(2S)-N-[(1S)-1-carbamoyl-5-{[(prop-2-en-1-yloxy)carbonyl]amino}pentyl]-3-phenyl-2-[(2R)-2-{[(prop-2-en-1-yloxy)carbonyl]amino}propanamido]propanamido]phenyl}methyl 4-nitrophenyl carbonate
- CAS：253863-34-2
- Formule moléculaire：C40H46N6O12
- Pureté：95%+
- Numéro de catalogue：CM339140
- Poids moléculaire：802.84
Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:253863-34-2
- Formule moléculaire:C40H46N6O12
- Point de fusion:-
- Code SMILES:O=C(N)[C@H](CCCCNC(OCC=C)=O)N(C([C@H](CC1=CC=CC=C1)NC([C@@H](C)NC(OCC=C)=O)=O)=O)C2=CC=C(COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)C=C2
- Densité:
- Numéro de catalogue:CM339140
- Poids moléculaire:802.84
- Point d'ébullition:
- N° Mdl:
- Stockage:
Category Infos
- ADC-Linkers
- The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
- Cleavable linkers
- Cleavable linkers rely on the inherent properties of a cell’s cytoplasmic compartments for selective release of the cytotoxic drug.
- Peptide linkers
- Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.
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