Nom du produit:Azidoethyl-SS-propionic NHS ester

IUPAC Name:2,5-dioxopyrrolidin-1-yl 3-[(2-azidoethyl)disulfanyl]propanoate

CAS:2243566-44-9
Formule moléculaire:C9H12N4O4S2
Pureté:95%+
Numéro de catalogue:CM339028
Poids moléculaire:304.34

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Détails du produit

N° CAS:2243566-44-9
Formule moléculaire:C9H12N4O4S2
Point de fusion:-
Code SMILES:O=C(ON1C(CCC1=O)=O)CCSSCCN=[N+]=[N-]
Densité:
Numéro de catalogue:CM339028
Poids moléculaire:304.34
Point d'ébullition:
N° Mdl:
Stockage:

Category Infos

ADC-Linkers
The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
Cleavable linkers
Cleavable linkers rely on the inherent properties of a cell’s cytoplasmic compartments for selective release of the cytotoxic drug.
N-Hydroxysuccinimide (NHS)
N-Hydroxysuccinimide
Azides
Azides are used in click chemistry, such as copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC),and strain-promoted [3+2] azide-alkyne cycloaddition reaction (SPAAC).
Disulfides/Thiols
In chemistry, a disulfide is a compound containing a R−S−S−R′ functional group or the S 2− anion. Thiols are the sulfur analogue of alcohols.

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