Nom du produit:tert-butyl N-[1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-yl]carbamate

IUPAC Name:tert-butyl N-[1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-yl]carbamate

CAS:2172875-14-6
Formule moléculaire:C19H23BrClN3O2
Pureté:95%+
Numéro de catalogue:CM1075011
Poids moléculaire:440.77

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Détails du produit

N° CAS:2172875-14-6
Formule moléculaire:C19H23BrClN3O2
Point de fusion:-
Code SMILES:CC(C)(C)OC(=O)NC1CCN(CC1)C1=C2C=C(Br)C=CC2=NC=C1Cl
Densité:
Numéro de catalogue:CM1075011
Poids moléculaire:440.77
Point d'ébullition:
N° Mdl:
Stockage:

Category Infos

Quinolines
Quinolines are an important class of biologically active heterocyclic compounds, and their derivatives usually exhibit a variety of biological activities. They can be used as antimalarial drugs and in the preparation of other antimalarial drugs. Other important activities of quinoline derivatives include inhibitory activity against EGFR-TK and antipsychotic activity. Futhermore, quinoline scaffolds are present in various drug molecules, including the antimalarial drugs aablaquine, chloroquine, mefloquine and primaquine, and the antibacterial agents gatifloxacin, levofloxacin, and moxifloxacin.
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Paltusotine
Crinetics’ once-daily oral paltusotine achieved the primary and all secondary endpoints in the phase 3 PATHFNDR-2 study in acromegaly patients.
Acromegaly is a serious rare disease generally caused by a pituitary adenoma, a benign tumor in the pituitary that secretes growth hormone (GH). Excess GH secretion causes excess secretion of IGF-1 from the liver. Prolonged exposure to increased levels of IGF-1 and GH leads to progressive and serious systemic complications, often resulting in bone, joint, cardiovascular, metabolic, cerebrovascular, or respiratory disease. 
Paltusotine is the first oral, once-daily selectively-targeted somatostatin receptor type 2 (SST2) agonist and is currently in investigational Phase 3 studies for acromegaly and a Phase 2 study for carcinoid syndrome.