cas 2137451-32-0|| where to buy 3-(oxiran-2-ylmethyl)oxetan-3-ol

Nom du produit:3-(oxiran-2-ylmethyl)oxetan-3-ol

IUPAC Name:3-[(oxiran-2-yl)methyl]oxetan-3-ol

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: N° CAS:2137451-32-0; Formule moléculaire:C6H10O3; Point de fusion:-; Code SMILES:OC1(CC2CO2)COC1; Densité:

: Numéro de catalogue:CM768499; Poids moléculaire:130.14; Point d'ébullition:; N° Mdl:MFCD30652071; Stockage:

: Oxetanes; Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.

: Oxiranes; Oxirane is a three-membered ring compound consisting of one oxygen atom and two carbon atoms. Oxirane is present in natural products such as cryptocin, which has anticancer properties, and azidomycin, trienone, and epoxidomycin, which have shown activity against drug-resistant leukemias and AIDS-related lymphomas. Other oxirane containing bioactive molecules have anti-inflammatory, immunosuppressive, and antitumor activities. Oxiranes are a strained ring susceptible to various nucleophilic, ring-opening or rearrangement reactions, so they are considered to be one of the most important intermediates in organic synthesis.