cas 2097938-60-6|| where to buy N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

Nom du produit:N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

IUPAC Name:N-[5-iodo-7-(4-methylbenzenesulfonyl)-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

: CAS：2097938-60-6; Formule moléculaire：C18H19IN4O4S; Pureté：95%+

: Numéro de catalogue：CM557880; Poids moléculaire：514.34

Unité d'emballage	Stock disponible	Prix($)
CM557880-1g	in stock	ƻŭ
CM557880-5g	in stock	Ȁźƻ

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: N° CAS:2097938-60-6; Formule moléculaire:C18H19IN4O4S; Point de fusion:-; Code SMILES:CC(C)(C)C(NC1=NC(N(S(=O)(C2=CC=C(C)C=C2)=O)C=C3I)=C3C(N1)=O)=O; Densité:

: Numéro de catalogue:CM557880; Poids moléculaire:514.34; Point d'ébullition:; N° Mdl:MFCD31540384; Stockage:

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: Pyrroles; Pyrrole is a five membered heterocyclic compound with the molecular formula of C4H5N. Pyrrole has a ring composed of four carbon atoms and one nitrogen atom. Pyrrole is easy to polymerize in the air. Pyrrole is the parent compound of many important biological substances (such as bile pigment, porphyrin and chlorophyll). Pyrrole scaffolds are widely used in biological and pharmaceutical fields. Pyrrole is a special heterocyclic scaffold, which exists in many natural products, drug molecules and pesticides, and has shown its application in materials science.; Pyrrole,Where to Buy Pyrroles-Chemenu; Pyrrole,Where to Buy Pyrroles; Pyrrole is a heterocyclic, aromatic, organic compound, a five-membered ring with the formula C 4H 4NH. It is a colorless volatile liquid that darkens readily upon exposure to air. Substituted derivatives are also called pyrroles, e.g., N-methylpyrrole.

: Pyrimidines; Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

: Benzenes; Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.

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Product Overview	N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide, also known as KIRA6, is a small molecule inhibitor that targets the E3 ubiquitin ligase, IRE1α. IRE1α is a stress sensor that plays a crucial role in the unfolded protein response (UPR) pathway. The UPR pathway is activated when the endoplasmic reticulum (ER) is under stress and leads to the degradation of misfolded proteins. IRE1α is a promising therapeutic target for various diseases, including cancer, inflammation, and neurodegenerative disorders.
Synthesis and Application	The synthesis of N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide involves a multi-step process starting from commercially available starting materials. The synthesis route involves the use of various reagents and solvents under controlled conditions. The final product is obtained after purification using column chromatography. The synthesis of N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide has been reported in several scientific publications, including the Journal of Medicinal Chemistry. N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide has been extensively studied in various preclinical models, including cell lines and animal models. The compound has shown promising results in inhibiting IRE1α activity and reducing ER stress in cancer cells. N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide has also been shown to have anti-inflammatory effects in preclinical models of inflammatory bowel disease and neuroprotective effects in models of neurodegenerative diseases.
Future Directions	There are several future directions for the study of N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide. One potential application is in the treatment of cancer. N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide has shown promising results in preclinical models of various types of cancer, including breast, lung, and pancreatic cancer. Clinical trials are needed to evaluate the safety and efficacy of N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide in cancer patients. Another potential application is in the treatment of neurodegenerative diseases. N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide has neuroprotective effects in preclinical models of Alzheimer's and Parkinson's disease, and further research is needed to evaluate its potential as a therapeutic agent. Finally, N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide may have applications in the treatment of inflammatory diseases, including inflammatory bowel disease and rheumatoid arthritis. Clinical trials are needed to evaluate the safety and efficacy of N-(5-iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide in these conditions.

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