Nom du produit:5-Bromo-6-methyl-1-(oxetan-3-yl)-1H-indazole
IUPAC Name:5-bromo-6-methyl-1-(oxetan-3-yl)-1H-indazole
- CAS：1562397-43-6
- Formule moléculaire：C11H11BrN2O
- Pureté：95%+
- Numéro de catalogue：CM535445
- Poids moléculaire：267.13
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Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:1562397-43-6
- Formule moléculaire:C11H11BrN2O
- Point de fusion:-
- Code SMILES:CC1=CC2=C(C=C1Br)C=NN2C3COC3
- Densité:
- Numéro de catalogue:CM535445
- Poids moléculaire:267.13
- Point d'ébullition:
- N° Mdl:
- Stockage:
Category Infos
- Indazoles
- Indazoles are a class of organic heterocyclic compounds, also known as 1,2-diazaindene and benzopyrazole. Indazole is a good bioisomer of phenol, which is more lipophilic than phenol and less prone to phase I and II metabolism. Indazole derivatives have a wide range of biological activities, and it has been confirmed that indazole compounds have anti-tumor, analgesic, anti-inflammatory and other drug activities. Anticancer is the most important application field of indazole drugs. Renal cell carcinoma, solid tumor, nausea and vomiting caused by chemotherapy and leukemia are the main indications of this structural backbone drug.
- Oxetanes
- Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.
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