Nom du produit:3-(1-(Cyclopropylmethyl)-1H-imidazol-4-yl)imidazo[1,5-a]pyridine-1-carboxylic acid
IUPAC Name:3-[1-(cyclopropylmethyl)-1H-imidazol-4-yl]imidazo[1,5-a]pyridine-1-carboxylic acid
- CAS：1422139-66-9
- Formule moléculaire：C15H14N4O2
- Pureté：95+%
- Numéro de catalogue：CM273865
- Poids moléculaire：282.3
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Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:1422139-66-9
- Formule moléculaire:C15H14N4O2
- Point de fusion:-
- Code SMILES:O=C(C1=C2C=CC=CN2C(C3=CN(CC4CC4)C=N3)=N1)O
- Densité:
- Numéro de catalogue:CM273865
- Poids moléculaire:282.3
- Point d'ébullition:
- N° Mdl:
- Stockage:
Category Infos
- Imidazoles
- Imidazole is an important five-membered nitrogen-containing heterocyclic compound. Among the numerous heterocyclic compounds, imidazole and its derivatives are regarded as a unique and multifaceted scaffold material due to their diverse applications in industrial, organic and pharmaceutical chemistry. Imidazoles interact in different ways with many therapeutic targets, enzymes and receptors in biological systems and thus exhibit a wide range of biological activities. In particular, several imidazoles can be used as clinical drugs to treat various types of cancer with high therapeutic efficacy. Furthermore, imidazoles are one of the most critical segments in the field of anti-covid-19 virus drug discovery due to their ability to interact with active targets in living systems.
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- Imidazopyridines
- With four imidazopyridine-containing drugs and one pyrazolopyridine-containing drug on the market, bicyclic pyridines containing ring-junction nitrogen are privileged structures in medicinal chemistry. With two nitrogen atoms with potential to serve as hydrogen bond acceptors, imidazopyridines and pyrazolopyridines may boost binding to target proteins and elevate potency. In addition, these structures have found utility in FBDD, covalent inhibitors, reducing metabolic liabilities, and creating novel chemical space and intellectual properties. With many of the advanced intermediates now commercially available, they will find more and more applications in drug discovery.
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- Cyclopropanes
- Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.
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