Nom du produit:N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
IUPAC Name:N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
- CAS:1421372-94-2
- Formule moléculaire:C20H16FN5O3
- Pureté:95%+
- Numéro de catalogue:CM147323
- Poids moléculaire:393.38
Pour une utilisation en R&D uniquement..
Détails du produit
- N° CAS:1421372-94-2
- Formule moléculaire:C20H16FN5O3
- Point de fusion:-
- Code SMILES:CN1C=C(C2=NC(NC3=CC([N+]([O-])=O)=C(F)C=C3OC)=NC=C2)C4=C1C=CC=C4
- Densité:
- Numéro de catalogue:CM147323
- Poids moléculaire:393.38
- Point d'ébullition:
- N° Mdl:MFCD28167946
- Stockage:Keep in dark place, store at 2-8°C.
Column Infos
- Indoles
- Indole is a compound of pyrrole and benzene in parallel, also known as benzopyrrole. There are two combinations of pyrrole and benzene, called indole and isoindole, respectively. Many derivatives of indole have physiological and pharmacological activities, and can synthesize vasodilators, antihistamines, antipyretic analgesics, etc. in medicine, so indole is also a very important heterocyclic compound.
- Osimertinib
- TAGRISSO (osimertinib) demonstrated overwhelming efficacy benefit for patients with unresectable, Stage III EGFR-mutated lung cancer in LAURA Phase III trial.
TAGRISSO (osimertinib) is a third-generation, irreversible EGFR-TKI with proven clinical activity in NSCLC, including against central nervous system metastases. It is the first and only EGFR TKI recommended by NCCN Guidelines as an adjuvant treatment option for completely resected stage IB-IIIA, stage IIIB (T3, N2) EGFRm (exon 19 deletion, exon 21 L858R mutation) NSCLC.