Nom du produit:tert-butyl (R)-3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidine-1-carboxylate

IUPAC Name:tert-butyl (3R)-3-{[6-(cyclopropylamino)pyrimidin-4-yl]oxy}pyrrolidine-1-carboxylate

CAS:1417789-30-0
Formule moléculaire:C16H24N4O3
Pureté:95%
Numéro de catalogue:CM166201
Poids moléculaire:320.39

Unité d'emballage Stock disponible Prix($) Quantité
CM166201-100mg in stock źșș
CM166201-250mg in stock ǯźň
CM166201-1g in stock șŔȀ

Pour une utilisation en R&D uniquement..

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Détails du produit

N° CAS:1417789-30-0
Formule moléculaire:C16H24N4O3
Point de fusion:-
Code SMILES:O=C(N1C[C@H](OC2=NC=NC(NC3CC3)=C2)CC1)OC(C)(C)C
Densité:
Numéro de catalogue:CM166201
Poids moléculaire:320.39
Point d'ébullition:
N° Mdl:MFCD22631758
Stockage:

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
Pyrrolidines
Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.
Cyclopropanes
Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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