Nom du produit:3-Bromo-6-chloroimidazo[1,2-b]pyridazine

IUPAC Name:3-bromo-6-chloroimidazo[1,2-b]pyridazine

CAS:13526-66-4
Formule moléculaire:C6H3BrClN3
Pureté:95%+
Numéro de catalogue:CM164495
Poids moléculaire:232.47

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Détails du produit

N° CAS:13526-66-4
Formule moléculaire:C6H3BrClN3
Point de fusion:-
Code SMILES:ClC1=NN2C(Br)=CN=C2C=C1
Densité:
Numéro de catalogue:CM164495
Poids moléculaire:232.47
Point d'ébullition:
N° Mdl:MFCD09027274
Stockage:Store at 2-8°C.

Category Infos

Imidazopyridazines
Potent IRAK-4 inhibitors have been reported by several groups including some structurally related benzimidazoles as well as alternative fused heterocycles such as the imidazopyridine and imidazopyridazine. Such compounds are reported to have IRAK-1 and IRAK-4 activity with varying degrees of selectivity.

Column Infos

Taletrectinib
Recently, Nuvation Bio announced positive pooled data from the pivotal Phase 2 TRUST-I and TRUST-II studies at the European Society for Medical Oncology (ESMO). Analysis showed that its small molecule taletrectinib, a new highly selective ROS1/NTRK kinase inhibitor, can cross the patient's blood-brain barrier to treat brain metastases, and nearly 90% of patients with advanced ROS1-positive non-small cell lung cancer (NSCLC) who received treatment had tumor shrinkage. In patients who had never been treated with tyrosine kinase inhibitors (TKIs), disease remission was sustained for nearly 4 years. Nuvation Bio plans to submit a new drug application (NDA) for the drug to the FDA in the fourth quarter of this year.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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