Nom du produit:3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinamide
IUPAC Name:3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-4-carboxamide
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| Product Overview |
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-YL)isonicotinamide, commonly known as TMI, is a boronic acid derivative that has gained significant attention in the scientific community due to its potential applications in various fields. |
| Synthesis Method |
The synthesis of TMI involves the reaction of 3-aminopyridine with 2-bromo-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in the presence of a palladium catalyst. The resulting compound is then treated with an acid to yield TMI. This synthesis method is relatively simple and efficient, making TMI a readily available compound for research purposes. |
| Chemical Properties |
It is relative ease of synthesis, making it readily available for research purposes. |
| Synthesis and Application |
It has been shown to exhibit potent inhibitory activity against various enzymes, including proteasomes and kinases, which are involved in the regulation of cellular processes. TMI has also been studied for its potential use as a fluorescent probe for the detection of metal ions. |
| Future Directions |
One potential direction is the further exploration of its potential applications in medicinal chemistry, particularly in the development of novel anticancer agents. Additionally, the use of TMI as a fluorescent probe for the detection of metal ions could be further explored. Finally, the development of more efficient synthesis methods for TMI could lead to its wider use in various fields of research. |
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