Nom du produit:2-(Azetidin-3-yl)-5-cyclopropylpyrimidine

IUPAC Name:2-(azetidin-3-yl)-5-cyclopropylpyrimidine

CAS:1236861-93-0
Formule moléculaire:C10H13N3
Pureté:95%
Numéro de catalogue:CM284700
Poids moléculaire:175.24

Unité d'emballage Stock disponible Prix($) Quantité
CM284700-1g 1-2 Weeks ŤŌǙ

Pour une utilisation en R&D uniquement..

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Détails du produit

N° CAS:1236861-93-0
Formule moléculaire:C10H13N3
Point de fusion:-
Code SMILES:C1(C2CNC2)=NC=C(C3CC3)C=N1
Densité:
Numéro de catalogue:CM284700
Poids moléculaire:175.24
Point d'ébullition:
N° Mdl:MFCD20528898
Stockage:

Category Infos

Pyrimidines
Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
Azetidines
Azetidines are an important class of saturated four-membered nitrogen-containing heterocyclic compounds. The research hotspots related to this structure mainly focus on two aspects: one is the research of pharmaceutical chemistry; the other is related to chiral azetidines, using rigid azetidine compounds as chiral ligands for asymmetric catalytic reactions. Many nitrogen-containing heterocycles play important roles in drug structures, and in many cases small structural changes can improve ligand selectivity and pharmacokinetic properties.
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Cyclopropanes
Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.